The story begins with a death. A famous 51-year-old actor by the name of Arthur Leander drops dead on stage of a massive heart attack during a performance of Shakespeare's King Lear. The actor's tragic death is soon overshadowed when a pandemic called the Georgia Flu effectively wipes out about 99% of the world's population. The web of characters that this story focuses on are all connected through Arthur Leander. Mandel does an excellent job of dropping hints, piquing interest and weaving this web of interconnection which snaps into focus at the climax of the story.
The character perspectives change as the story unfolds, so parts of the story take place before the world is forever altered by the Georgia Flu. In these chapters we get to know Arthur, his upbringing, his struggle as an actor, and the turbulent relationships with his many wives, but mainly his first wife, Miranda Carroll. Miranda, hailing from the same tiny island as Arthur, is fresh out of an abusive relationship when Arthur sweeps her away to Los Angeles. L.A. life could not be any less suited to anyone as it is for Miranda, and she throws herself into her creative endeavors to escape the resultant unhappiness of her lonely marriage.